Neuropsychological and Genetic Differences Between Age‐Associated Memory Impairment and Mild Cognitive Impairment Entities

• DOI: 10.1046/j.1532-5415.2001.49191.x
• Publication Date: 2003-05-09T13:48:13Z
• Authors: David Bartrés‐Faz; Carme Junqué; Antoni López‐Alomar; Neus Valveny; Pedro Moral; Robert Casamayor; Antoni Salido; Carme Bel; Imma C. Clemente
• Keywords: Apolipoprotein E; Memory Impairment; Neuropsychological Assessment; Memory clinic

OBJECTIVE: To neuropsychologically and genetically compare age‐associated memory impairment (AAMI) mild cognitive (MCI) entities to determine what proportion of AAMI diagnosed individuals could also receive a MCI diagnosis. the distribution previously known genetic risk factor for Alzheimer's disease (apolipoprotein E common polymorphism) associated with these two conditions sample normal aging. DESIGN: Neuropsychological assessments in individuals. Genetic assessment AAMI, MCI, control subjects. SETTING: General health centers geriatric homes from northeastern Spain (Catalunya). PARTICIPANTS: One hundred four subjects presenting subjective complaints were selected criteria applied. twenty‐four healthy Spanish age 50 older defined as controls. MEASUREMENTS: Memory, language, frontal lobe functions assessed using standard neuropsychological tests. The apolipoprotein (apo E) polymorphism was obtained by polymerase chain reaction (PCR) HhaI restriction endonuclease. RESULTS: Sixty‐seven percent be identified These cases differed those only‐AAMI both analyses, performing worse not only on but language tests high low prevalences apo ε3/ε4 ε3/ε3 genotypes, respectively. general 93 controls genotype allele distributions differences no longer present after subtracting (63 subjects). findings reflect that between impaired regarding mainly attributable who received diagnosis alone. CONCLUSIONS: Our suggest among subjects, fulfill profile closer related than eligible AAMI. However, our still appears select population differs population.