Non-contact force sensing for real-time stressing of biological cells

• DOI: 10.1049/mnl.2010.0230
• Publication Date: 2011-05-20T17:07:19Z
• Authors: Ming Li Han; Yan Liang Zhang; Meng Ying Yu; Cheng Yap Shee; Wei Tech Ang
• Keywords: Contact force; Strain (injury); Biological cell; Reaction; Cell membrane

Mechanical force sensing is an important and integral component in the study of viscoelastic properties biological cells. In this study, a vision-based non-contact technique for real-time stressing cells by vision-guided robotic micromanipulation system introduced. The capable providing external mechanical on with predefined profile estimating cell membrane deformation using proposed strain model. One phenomena manifesting gradual reduction reaction compressive stress under cyclic loading. applied respect to number cycles modelled validated different zebrafish embryos. experimental results show that model can estimate average maximum error 10.07%.