Association Between Molecular Subtypes of Colorectal Cancer and Patient Survival

• DOI: 10.1053/j.gastro.2014.09.038
• Publication Date: 2014-10-01T00:47:46Z
• Authors: Amanda I. Phipps; Paul J. Limburg; John A. Baron; Andrea N. Burnett...; Daniel J. Weisenb...; Peter W. Laird; Frank A. Sinicrope; Christophe Rosty; Daniel D. Buchanan; John D. Potter; Polly A. Newcomb
• Keywords: Adult; Male; Proto-Oncogene Proteins B-raf; DNA Mutational Analysis; Trial Calgb 89803; 610; Kaplan-Meier Estimate; Methylation; Disease-Free Survival; Defective mismatch repair; 03 medical and health sciences; 0302 clinical medicine; Proto-Oncogene Proteins; Biomarkers, Tumor; Humans; 2715 Gastroenterology; Genetic Predisposition to Disease; Prognostic significance; Stage-II; Oncogene; Aged; Proportional Hazards Models; Serrated colorectal cancer; Prognostic factor; Island methylator phenotype; III colon cancer; KRAS mutation; DNA Methylation; Middle Aged; 16. Peace & justice; 3. Good health; Braf V600E mutation; Phenotype; Mutation; Microsatellite instability; CpG Islands; Female; Microsatellite Instability; Colorectal Neoplasms; Clinicopathological features

Colorectal cancer (CRC) is a heterogeneous disease that can develop via several pathways. Different CRC subtypes, identified based on tumor markers, have been proposed to reflect these pathways. We evaluated the significance of these previously proposed classifications to survival.