Dietary Habits and Their Relations to Insulin Resistance and Postprandial Lipemia in Nonalcoholic Steatohepatitis

• DOI: 10.1053/jhep.2003.50132
• Publication Date: 2003-04-07T20:06:02Z
• Authors: Giovanni Musso; Roberto Gambino; Franco De Michieli; Maurizio Cassader; Mario Rizzetto; Marilena Durazzo; Emanuela Fagà; Barbara Silli; Gianfranco Pagano
• Keywords: Adult; Male; Metabolic Syndrome; 2. Zero hunger; 0301 basic medicine; 0303 health sciences; Alanine Transaminase; Glucose Tolerance Test; Lipoproteins, VLDL; Middle Aged; Postprandial Period; Dietary Fats; Lipids; Diet Records; Diet; Fatty Liver; 03 medical and health sciences; Humans; Female; Insulin Resistance; Triglycerides

The relations of dietary habits to insulin sensitivity and postprandial triglyceride metabolism were evaluated in 25 patients with nonalcoholic steatohepatitis (NASH) age–, body mass index (BMI)–, gender–matched healthy controls. After a 7–day alimentary record, they underwent standard oral glucose tolerance test (OGTT), the (ISI) was calculated from OGTT; an fat load also performed 15 intake NASH richer saturated (13.7% ± 3.1% vs. 10.0% 2.1% total kcal, respectively, P = .0001) cholesterol (506 108 405 111 mg/d, .002) poorer polyunsaturated (10.0% 3.5% 14.5% 4.0% fat, .0001), fiber (12.9 4.1 23.2 7.8 g/d, .000), antioxidant vitamins C (84.3 43.1 144.2 63.1 E (5.4 1.9 8.7 2.9 .0001). ISI significantly lower than Postprandial very low density lipoproteins at +4 hours +6 hours, area under curve, incremental curve higher compared Saturated correlated ISI, different features metabolic syndrome, rise triglyceride. apolipoprotein (Apo) B48 ApoB100 responses flat strikingly dissociated response, suggesting defect ApoB secretion. In conclusion, may promote directly by modulating hepatic accumulation activity as well indirectly affecting metabolism. Our findings provide further rationale for more specific interventions, particularly nonobese, nondiabetic normolipidemic patients.