Importance of extensive staging in patients with mucosa-associated lymphoid tissue (MALT)-type lymphoma

• DOI: 10.1054/bjoc.2000.1308
• Publication Date: 2002-07-26T11:30:24Z
• Authors: M Raderer; F Vorbeck; M Formanek; C Österreicher; J Valencak; M Penz; G Kornek; G Hamilton; B Dragosics; A Chott
• Keywords: Mucosa-associated lymphoid tissue

Lymphoma of the mucosa-associated lymphoid tissue (MALT) type usually arises in MALT acquired through chronic antigenic stimulation triggered by persistent infection and/or autoimmune processes. Due to specific ligand-receptor interactions between cells and high-endothelial venules MALT, both normal neoplastic display a pronounced homing tendency throughout body. In case disease these properties may be responsible for lymphoma dissemination among various MALT-sites. According this concept, we have standardized staging procedures all patients diagnosed with MALT-type lymphoma. All underwent before treatment. Staging included ophthalmologic examination, otolaryngologic investigation, gastroscopy multiple biopsies, endosonography upper gastrointestinal tract, enteroclysis, colonoscopy, computed tomography thorax abdomen bone marrow biopsy. Biopsy was performed lesions suggestive lymphomatous involvement, evaluation biopsy specimens reference pathologist. 35 consecutive histologically verified were admitted our department. Twenty-four (68%) had primary involvement stomach, five (15%) ocular adnexa, three (8.5%) parotid, (8,5%) lung. Lymph-node corresponding stage EII found 13 (37%), only one patient gastric local supradiaphragmatic lymph-node (stage EIII). Bone biopsies negative patients. Overall, eight (23%) simultaneous biopsy-proven two MALT-sites: each parotid lacrimal gland, conjunctiva hypopharynx, skin, gland lung, stomach colon, The remaining bilateral parotideal work-up importance extensive is emphasized demonstration multiorgan almost quarter addition, data suggest that extra-gastrointestinal more frequently occurs simultaneously at different anatomic sites than involving GI-tract.