Serum midkine levels are increased in patients with various types of carcinomas

• DOI: 10.1054/bjoc.2000.1339
• Publication Date: 2002-07-26T11:27:09Z
• Authors: S Ikematsu; A Yano; K Aridome; M Kikuchi; H Kumai; H Nagano; K Okamoto; M Oda; S Sakuma; T Aikou; H Muramatsu; K Kadomatsu; T Muramatsu
• Keywords: Midkine

The level of expression midkine (MK), a heparin-binding growth factor, is increased in many types human carcinomas. An enzyme-linked immunoassay, which utilizes combination rabbit and chicken antibodies revealed that serum MK the controls (n= 135) was 0.154 ± 0.076 (mean SD) ng ml–1with an apparent cut-off value as 0.5 ml–1. Serum significantly elevated cancer patients 150) (P< 0.001); 87% showed levels more than All ten examined similar profile level. There no or weak correlation between C-reactive protein level, marker inflammation, Furthermore, case gastric carcinoma lung carcinoma, with stage I already levels. present results indicated could serve general tumour good potential for clinical application. © 2000 Cancer Research Campaign