Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma

• DOI: 10.1054/bjoc.2000.1580
• Publication Date: 2002-07-26T11:31:53Z
• Authors: Y Ito; T Takeda; M Sakon; M Tsujimoto; S Higashiyama; K Noda; E Miyoshi; M Monden; N Matsuura
• Keywords: Male; Carcinoma, Hepatocellular; Receptor, ErbB-4; Time Factors; Receptor, ErbB-3; Receptor, ErbB-2; Liver Neoplasms; Regular Article; Middle Aged; Immunohistochemistry; Disease-Free Survival; 3. Good health; ErbB Receptors; 03 medical and health sciences; 0302 clinical medicine; Liver; Humans; Female; Neoplasm Invasiveness; Neoplasm Metastasis; Follow-Up Studies; Retrospective Studies

In order to elucidate the clinical significance of the erbB family, epidermal growth factor receptor (EGF-R), c-erbB-2, c-erbB-3 and c-erbB-4 in hepatocellular carcinoma (HCC), we investigated the expression of these proteins by means of immunohistochemistry for HCC as well as adjacent noncancerous lesions. EGF-R was expressed in 68% of the HCC examined and showed correlation with the proliferating activity, stage, intrahepatic metastasis and carcinoma differentiation. c-erbB-2 was expressed in only 21% of the cases and showed no relationships with the clinicopathological parameters. c-erbB-3 protein was observed in 84% of the HCC and 38.1% of the noncancerous lesions. Its expression in HCC was equal to or greater than noncancerous lesions in 90.5% of the cases, and was related to the stage, portal invasion, cell proliferating activity, tumour size, intrahepatic metastasis and carcinoma differentiation. c-erbB-4 protein was expressed in 61.0% of HCC and in as much as 86.1% of the noncancerous lesions. Unlike the expression of c-erbB-3, that of c-erbB-4 in HCC was less than that of the adjacent noncancerous lesions in 51.2% of the cases. No statistical significance could be established between this protein expression in HCC and clinicopathological features. EGF-R and c-erbB-3 affected disease-free survival, but were not recognized as independent prognostic factors by multivariate analysis. The present study suggests that, of the four receptors, EGF-R and c-erbB-3 play important roles in the progression of HCC.