Development of pulmonary bronchiolo-alveolar adenocarcinomas in transgenic mice overexpressing murine c- myc and epidermal growth factor in alveolar type II pneumocytes

• DOI: 10.1054/bjoc.2000.1676
• Publication Date: 2002-07-26T07:30:18Z
• Authors: A Ehrhardt; T Bartels; A Geick; R Klocke; D Paul; R Halter
• Keywords: Surfactant protein C; Alveolar cells; Pulmonary alveolus; Alveolar Epithelium

Transgenic mouse models were established to study tumorigenesis of bronchiolo-alveolar adenocarcinomas derived from alveolar type II pneumocytes (AT-II cells). lines expressing the murine oncogene c- myc under control lung-specific surfactant protein C promoter developed multifocal hyperplasias, adenomas and carcinomas respectively, whereas transgenic a secretable form epidermal growth factor (IgEGF), structural functional homologue transforming alpha (TGF alpha), hyperplasias epithelium. Since oncogenes TGF are frequently overexpressed in human lung adenocarcinomas, these useful as for adenocarcinomas. The average life expectancies hemizygous homozygous transgenics 14.25 months 9.2 months, suggesting that dosage effect caused an accelerated adenocarcinoma formation. First analyses double transgenics, both IgEGF, show mice develop at age 9 indicating cooperate during cancer Our results demonstrate EGF directly involved with one another formation lung.