Chromosomal radiosensitivity in G2-phase lymphocytes identifies breast cancer patients with distinctive tumour characteristics

• DOI: 10.1054/bjoc.2001.2086
• Publication Date: 2002-07-26T11:29:31Z
• Authors: A C Riches; P E Bryant; C M Steel; A Gleig; A J Robertson; P E Preece; A M Thompson
• Keywords: Radiosensitivity

A substantial proportion of women with breast cancer exhibit an abnormally high radiosensitivity as measured by the frequency chromatid breaks induced in G2-phase, PHA stimulated lymphocytes. Chromatid break frequencies were compared for a cohort previously untreated sporadic patients and hospital outpatient controls. In group 46% showed to 14% controls (P< 0.001). Comparison those G2radiosensitivity (G2RS) versus low G2RS no difference menopausal status or age but had on average lower score Nottingham Prognostic Index. Predicted survival at 15 years was 55% 36% group. Furthermore, 81% tumours from oestrogen receptor positive 45% Thus identifies sub-population distinctive tumour characteristics predicted improved prognosis Our findings imply that besides influencing risk genetic factors determining also influence these patients. © 2001 Cancer Research Campaign http://www.bjcancer.com