Chromosomal radiosensitivity in G2-phase lymphocytes identifies breast cancer patients with distinctive tumour characteristics
Radiosensitivity
DOI:
10.1054/bjoc.2001.2086
Publication Date:
2002-07-26T11:29:31Z
AUTHORS (7)
ABSTRACT
A substantial proportion of women with breast cancer exhibit an abnormally high radiosensitivity as measured by the frequency chromatid breaks induced in G2-phase, PHA stimulated lymphocytes. Chromatid break frequencies were compared for a cohort previously untreated sporadic patients and hospital outpatient controls. In group 46% showed to 14% controls (P< 0.001). Comparison those G2radiosensitivity (G2RS) versus low G2RS no difference menopausal status or age but had on average lower score Nottingham Prognostic Index. Predicted survival at 15 years was 55% 36% group. Furthermore, 81% tumours from oestrogen receptor positive 45% Thus identifies sub-population distinctive tumour characteristics predicted improved prognosis Our findings imply that besides influencing risk genetic factors determining also influence these patients. © 2001 Cancer Research Campaign http://www.bjcancer.com
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (0)
CITATIONS (52)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....