Endoscopic tissue shielding to prevent bleeding after endoscopic submucosal dissection: a prospective multicenter randomized controlled trial

• DOI: 10.1055/a-0860-5280
• Publication Date: 2019-03-25T15:16:43Z
• Authors: Yosuke Kataoka; Yosuke Tsuji; Kingo Hirasawa; Kengo Takimoto; Tomonori Wada; Satoshi Mochizuki; Ken Ohata; Yoshiki Sakaguchi; Keiko Niimi; Satoshi Ono; Shinya Kodashima; Nobutake Yamamichi; Mitsuhiro Fujishiro; Kazuhiko Koike
• Keywords: Endoscopic submucosal dissection; Clinical endpoint

Bleeding after endoscopic submucosal dissection (ESD) is a severe adverse event. Recent reports have described the efficacy of shielding method with polyglycolic acid (PGA) sheets and fibrin glue for prevention events ESD. The aim present study was to investigate whether PGA provides additional benefit in preventing post-ESD bleeding compared standard care.This prospective, multicenter, randomized controlled trial. Patients at high risk were enrolled study. Before ESD, patients either group or control group. After completing ESD group, placed onto ulcer floor adhered glue. primary end point rate.140 eligible from September 2014 2016, 137 included intention-to-treat analysis (67 70 group). Post-ESD occurred three (4.5 %) four (5.7 group; there no significant difference between two groups (P > 0.99). tended occur later than (median 12.5 days [range 8 - 14] vs. 2 0 7], respectively).The did not demonstrate effect on bleeding.