Virucidal Effect of Guggulsterone Isolated from Commiphora gileadensis

• DOI: 10.1055/a-1014-3303
• Publication Date: 2019-10-07T23:14:07Z
• Authors: Lamjed Bouslama; Bochra Kouidhi; Yasir Mohammed Al...; Kamel Chaieb; Adele Papetti
• Keywords: virucidal activity; 0301 basic medicine; Herpesvirus 2, Human; herpes simplex virus type 2; 610; respiratory syncytial virus type B; Commiphora gileadensis; guggulsterone; Antiviral Agents; Adenoviridae; Enterovirus B, Human; Respiratory Syncytial Viruses; 3. Good health; 03 medical and health sciences; Pregnenediones; cytotoxicity; Medicine, Traditional; Burseraceae; Commiphora

Abstract Commiphora gileadensis, locally known as becham, is a plant used in traditional Arabian medicine for treating headache, constipation, stomach, joint pain, and inflammatory disorders. Several studies have reported its antibacterial properties; however, no study has demonstrated antiviral activity. This aimed to evaluate the activity of C. gileadensis well isolate active compound investigate mode action. was evaluated using 4 viruses, herpes simplex virus type 2 (HSV-2), respiratory syncytial B (RSV-B), coxsackie 3, adenovirus 5 by performing plaque reduction assay 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays enveloped nonenveloped respectively. The methanol extract leaves only showed against viruses with selectivity index 11.19 10.25 HSV-2 RSV-B, mechanism underlying virucidal effect direct contact these target viruses. compound, isolated bio-guided involving TLC, identified guggulsterone HPLC-diode array detection coupled electrospray ionization mass spectrometry. Guggulsterone an antagonist bile acid receptor modulator cholesterol metabolism; antimicrobial properties been first time this study.