Establishing 17-Hydroxyprogesterone Cutoff Values for Congenital Adrenal Hyperplasia in Preterm, Low Birth Weight, and Sick Newborns

• DOI: 10.1055/a-2022-8399
• Publication Date: 2023-03-01T00:05:46Z
• Authors: Young Ahn Yoon; Suhyeon Woo; Min-Sun Kim; Bohyun Kim; Young-Jin Choi
• Keywords: Cut-off

Newborn screening for congenital adrenal hyperplasia (CAH) has benefits with a high adoption rate worldwide. It also problems of false positives, which can cause stress to the patient's family economic losses and unnecessary visits newborns hospitals. Therefore, we investigated influence birth weight (BW), gestational age (GA), GA sampling time on 17-hydroxyprogesterone (17-OHP) concentration attempted establish 17-OHP cutoff values in preterm, low (LBW), sick newborns.Newborns (n=1,071) born between October 2020 January 2022 were screened CAH. Samples from neonates collected filter paper heel prick method. was measured by time-resolved immunofluorescence an AutoDELFIA Neonatal 17-hydroxyprogesteron kit grouped relation BW, GA, time.The median at neonatal sample collection 6 days. showed statistically significant negative correlation BW (r=-0.488, p<0.001) (r=-0.560, p<0.001). Full-term preterm subgroups had similar decreasing tendency increasing time. Application newly establishing criteria significantly reduced recall rates 1.16%, 0.9%, 1.75% according each criterion time, respectively.This study presents new LBW, newborns. These data our laboratory be used as reference other laboratories help lower reduce follow-up tests.