Rapid and Selective in situ Reduction of Pyridine-N-oxides with Tetra­hydroxydiboron

• DOI: 10.1055/s-0033-1340010
• Publication Date: 2013-11-05T18:39:45Z
• Authors: Allyn Londregan; David Piotrowski; Jun Xiao
• Keywords: Pyridine-N-oxide; Tetra; Reducing agent; Selective Reduction

Pyridine-<i>N</i>-oxides are often used as reactive precursors in the syntheses of substituted pyridines. Isolation and subsequent reduction associated pyridine-<i>N</i>-oxide intermediates can be challenging. We have discovered that tetrahydroxydiboron functions a mild, versatile, remarkably selective reducing agent for pyridine-<i>N</i>-oxides may an situ fashion, thus ­obviating isolation <i>N</i>-oxide-containing