Design Aspects of Metal-Free Nitrogen-Based Catalysts and Their Influence on the Yield in the Henry Reaction

• DOI: 10.1055/s-0033-1341125
• Publication Date: 2014-04-18T04:09:13Z
• Authors: Zaher Judeh; Qiong Yao; Duc Khong; Qi Gao
• Keywords: Imine; Nitroaldol reaction; Nitroethane

Design aspects of metal-free nitrogen-based catalysts and their influence on the yield in Henry reaction are disclosed. <i>C</i> ₁-Symmetric, <i>N</i>,<i>N</i>-1,2-disposed amine-imine type were found to be most efficient. ₁-<i>N</i>,<i>N</i>-1,2-Disposed 1,2,3,4-tetrahydro-1,1′-biisoquinoline selectively efficiently catalyzed addition nitromethane α-keto esters aldehydes giving exclusively corresponding β-nitro alcohol adducts excellent yields under very mild conditions.