Synthesis of Trifluoromethylated Azetidines, Aminopropanes, 1,3-Oxazinanes, and 1,3-Oxazinan-2-ones Starting from 4-Trifluoromethyl-β-lactam Building Blocks

• DOI: 10.1055/s-0035-1561316
• Publication Date: 2016-01-20T23:40:20Z
• Authors: Tuyen Van Nguyen; Matthias D’hooghe; Hang Dao Thi; Lena Decuyper; Karen Mollet; Sara Kenis; Norbert De Kimpe
• Keywords: Lactam

This paper reports on the preparation of 4-(trifluoromethyl)azetidin-2-ones and their synthetic potential as eligible new building blocks for construction CF₃-containing azetidines, diaminopropanes, aminopropanol derivatives, 1,3-oxazinanes, 1,3-oxazinan-2-ones. β-lactam block approach provides a convenient entry into trifluoromethylated scaffolds useful intermediates <i>en route</i> to variety CF₃-functionalized target structures.