Radical Addition/Cyclization Cascade: An Efficient Approach to Nitro-Containing Quinoline-2,4(1H,3H)-diones

• DOI: 10.1055/s-0037-1610070
• Publication Date: 2018-06-18T19:02:45Z
• Authors: Ya-Min Li; Tao Yang; Jia-Li Zhou; Junpeng Li; Yuehai Shen; Chuanzhu Gao
• Keywords: Quinoline; Radical cyclization; Scope (computer science); Cascade reaction; Functional group

A radical addition/cyclization cascade of o-cyanoarylacrylamides with magnesium nitrate hexahydrate is developed. This reaction exhibits good functional group tolerance and wide substrate scope, provides a highly efficient practical access to nitro-containing quinoline-2,4(1H,3H)-diones.