Assessment of a Bleeding Risk Index in Two Cohorts of Patients Treated with Oral Anticoagulants

• DOI: 10.1055/s-0038-1650514
• Publication Date: 2018-07-10T22:31:17Z
• Authors: F J M van der Meer; F R Rosendaal; J P Vandenbroucke; E Briët
• Keywords: Rate ratio

Summary In two cohorts of patients on oral anticoagulant therapy, routinely treated by the Leiden Thrombosis Service, frequency major bleeding complications was assessed during years (1988 and 1991). With Poisson regression analysis influence risk factors age, sex, target zone, achieved INR type coumarin derivative used were determined. Subsequently, a index calculated, combining results cohorts. For various types relative assessed. Age most important consistent factors: rate ratio (RR) for age in 1988 1.46 per 10 increase (95% confidence interval [Cl] 1.20-1.78) 1991 1.57 Cl 1.23-2.00); RR unit 1.42 1.21-1.68) 1.44 1.18-1.74). Two methods to combine 1991. first method mean calculated: (incidence) [natural logarithm incidence bleeding] = -5.64 +0.42 * +0.26 % sex -0.29 range +0.36 -0.36 type. second only used: INR. These indexes can be assess individual allow more individualized care tailoring desired anticoagulation.