Severe Anemia Is Associated with Intestinal Injury in Preterm Neonates

• DOI: 10.1055/s-0039-1683982
• Publication Date: 2019-04-04T22:50:39Z
• Authors: Beyza Ozcan; Ozge Aydemir; Dilek Ulubas Isik; Ahmet Yagmur Bas; Nihal Demirel
• Keywords: Male; Infant, Newborn; Anemia; Infant, Premature, Diseases; Fatty Acid-Binding Proteins; 3. Good health; Hemoglobins; 03 medical and health sciences; 0302 clinical medicine; Enterocolitis, Necrotizing; Case-Control Studies; Humans; Infant, Very Low Birth Weight; Female; Prospective Studies; Erythrocyte Transfusion; Infant, Premature

Abstract Objective A temporal relationship has been reported between necrotizing enterocolitis, anemia, and red blood cell transfusion (RBCT) in preterm neonates. However, the mechanism underlying this association is not clearly defined. Intestinal (I-) liver (L-) fatty acid binding proteins (FABPs) have proposed as plasma markers for detection of acute intestinal injury. This study aimed to investigate effect anemia RBCT on injury neonates by measuring serum I-FABP L-FABP levels. Study Design prospective cohort including with gestational age <32 weeks and/or birth weight <1,500 g requiring erythrocyte transfusions after day 15 life was conducted. Stable growing infants hemoglobin values ≥ 10 g/dL were taken controls. levels compared control group. In addition, pretransfusion posttransfusion Results total, 39 transfused 20 controls enrolled. significantly higher (p < 0.001), whereas = 0.695) different. similar before anemia. negatively correlated 0.001). Conclusion Anemia associated documented increased infants, more severe lower