The Cancer-Associated Fibroblast and Hypoxia Nexus: Correlation between 68Ga-FAPI PET and Hypoxia Inducible Factor-1alpha Immunohistochemistry

• DOI: 10.1055/s-0043-1769969
• Publication Date: 2023-06-13T20:40:12Z
• Authors: Kgomotso Mokoala; Ismaheel Lawal; Letjie Maserumule; Khanyisile Hlongwa; Honest Ndlovu; Janet Reed; Johncy Mahapane; Cindy Davis; Meshack Bida; Alex Maes; Chris van de Wiele; Gbenga Popoola; Frederik Giesel; Mariza Vorster; Mike Sathekge
• Keywords: Hypoxia; Hypoxia-Inducible Factors; HIF1A; Tumor Hypoxia

Introduction: Cervical cancer lesions, like most solid tumors, grow large, and outgrow their blood supply which leads to hypoxia. Hypoxia has been shown upregulate the presence functions of associated fibroblasts (CAFs) results in increased aggressiveness. inducible factor-1α (HIF-1α) is a well-studied marker PET imaging gynecological cancers with 68Ga-FAPI documented. We aimed utilize as surrogate tracer hypoxia we correlated findings immunohistochemical analysis HIF-1α expression.