Plasma Glucose-Lowering Effect of β-Endorphin in Streptozotocin-Induced Diabetic Rats

• DOI: 10.1055/s-2002-35418
• Publication Date: 2002-11-19T09:30:24Z
• Authors: J. T. Cheng; I. M. Liu; T. F. Tzeng; C. C. Tsai; T. Y. Lai
• Keywords: Chelerythrine; beta-Endorphin

The effect of beta-endorphin on plasma glucose levels was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). A dose-dependent lowering observed the fasting STZ-diabetic rat fifteen minutes after intravenous injection beta-endorphin. glucose-lowering abolished by pretreatment with naloxone or naloxonazine at doses sufficient to block opioid mu-receptors. Also, unlike wild-type mice, failed induce its mu-receptor knock-out mice. In isolated soleus muscle, enhanced uptake radioactive a concentration-dependent manner. Stimulatory effects glycogen synthesis were also seen hepatocytes from rats. blockade these actions and indicated mediation presence U73312, specific inhibitor phospholipase C (PLC), into muscle induced reduced manner, but it not affected U73343, negative control U73312. Moreover, chelerythrine GF 109203X diminished stimulatory action concentration inhibit protein kinase (PKC). data obtained suggest that activating mu-receptors may increase utilization peripheral tissues via PLC-PKC pathway lower lacking insulin.