Kontrollierte Inhalation von β2-Sympathikomimetika nach bronchialem Provokationstest

• DOI: 10.1055/s-2003-44262
• Publication Date: 2003-11-17T10:23:59Z
• Authors: T. Meyer; P. Brand; C. Herpich; G. Scheuch; N. Weber
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

The results of several studies indicate that controlling the breathing pattern (inhaled volume and flow rate) during inhalation increases the efficacy of drug delivery to the lungs. By inhaling slowly, deeply and under controlled conditions, intrapulmonary deposition of aerosol and its reproducibility can be increased. However, it has not yet been proven that such inhalations are well tolerated by patients, especially those with airway obstructions. In this study 12 patients with mild asthma underwent a bronchial provocation test. The following broncholysis was performed with controlled, slow, and deep inhalation using the AKITA-device. The patients were asked about the convenience of this inhalation using a questionnaire. In 80 % the controlled inhalation was judged as convenient, neither as too slow nor as too fast, neither as too deep nor as too shallow. Thus it turned out that controlled deep and slow inhalations are convenient even for patients with mild airway obstruction.