Cinnamon Extract Prevents the Insulin Resistance Induced by a High-fructose Diet

• DOI: 10.1055/s-2004-814223
• Publication Date: 2004-03-05T03:56:26Z
• Authors: Bolin Qin; Masaru Nagasaki; Ming Ren; Gustavo Bajotto; Y. Oshida; Youichi Sato
• Keywords: IRS1; Glucose clamp technique

The aim of this study was to determine whether cinnamon extract (CE) would improve the glucose utilization in normal male Wistar rats fed a high-fructose diet (HFD) for three weeks with or without CE added drinking water (300 mg/kg/day). In vivo measured by euglycemic clamp technique. Further analyses on possible changes insulin signaling occurring skeletal muscle were performed afterwards Western blotting. At 3 mU/kg/min infusions, decreased infusion rate (GIR) HFD-fed (60 % controls, p < 0.01) improved administration same level controls (normal chow diet) and improving effect GIR blocked approximately 50 N-monometyl-L-arginine. tendency found during 30 infusions. There no differences receptor (IR)-β, IR substrate (IRS)-1, phosphatidylinositol (PI) 3-kinase protein content any groups. However, muscular insulin-stimulated IR-β IRS-1 tyrosine phosphorylation levels associated PI only 70 ± 9 %, 76 5 72 6 (p 0.05), respectively, these decreases significantly treatment. These results suggest that early prevent development resistance at least part enhancing possibly via NO pathway muscle.