Deoxypodophyllotoxin, a Naturally Occurring Lignan, inhibits the Passive Cutaneous Anaphylaxis Reaction

• DOI: 10.1055/s-2004-818981
• Publication Date: 2004-05-04T09:22:24Z
• Authors: Eunkyung Lee; Jong Keun Son; Hye Kyung Ju; Mi Jeong Kim; Min Jung Son; Hyeun Wook Chang; Seung Ho Lee; So Hee Kim; Tae Chul Moon; Chang Xiu Lin
• Keywords: Hypersensitivity, Immediate; Male; 0303 health sciences; Dose-Response Relationship, Drug; Plant Extracts; Passive Cutaneous Anaphylaxis; Plant Roots; Lignans; Rats; 3. Good health; Rats, Sprague-Dawley; 03 medical and health sciences; Injections, Intravenous; Animals; Injections, Intraperitoneal; Apiaceae; Drugs, Chinese Herbal; Phytotherapy; Podophyllotoxin

This study examined the effect of a podophyllotoxin derivative, deoxypodophyllotoxin (anthricin), which is a medicinal herb product isolated from Anthriscus sylvestris Hoffm. Deoxypodophyllotoxin was tested in a rat PCA (passive cutaneous anaphylaxis) assay by administering deoxypodophyllotoxin intraperitoneally (1.0 to 10 mg/kg, i.p.) and intravenously (0.25 to 1.0 mg/kg, i.v.). Deoxypodophyllotoxin dose-dependently inhibited the PCA reaction activated by anti-dinitrophenyl (DNP) IgE. The PCA inhibitory activity of deoxypodophyllotoxin was stronger than those of prednisolone and indomethacin, which were used as positive controls. These results suggest that deoxypodophyllotoxin may be beneficial in regulating the immediate-type allergic reaction.