Histological Analysis of Endoscopic Resection Specimens From 326 Patients with Barrett’s Esophagus and Early Neoplasia

• DOI: 10.1055/s-2004-825802
• Publication Date: 2004-08-24T07:55:56Z
• Authors: M. Vieth; C. Ell; L. Gossner; A. May; M. Stolte
• Keywords: Endoscopic mucosal resection; Lymphovascular invasion; Barrett's esophagus

Endoscopic resection has been recommended as a local curative approach for Barrett's neoplasia, but large series are still rare. In the present study we analyzed histological characteristics of endoscopic specimens neoplasia.742 obtained from 326 patients were assessed. The following evaluated: type grade differentiation, depth infiltration, invasion into lymphatic and blood vessels, status (tumor-free margins regarded indicating R0 status).31 had no neoplasia excluded analysis. Among remaining 295 (711 specimens), findings were: low-grade intraepithelial 1.0 %; high-grade 2.7 mucosal carcinoma 80.3 %. Carcinomas infiltrating submucosal layer rare (sm1 7.5 sm2 3.7 sm3 4.8 %), those invading lymph vessels (3.5 there none with venous invasion. Most carcinomas well-differentiated (72.2 many these (92.7 %) limited to mucosa, in contrast moderately poorly differentiated (73.7 % 22.7 %, respectively). was achieved 74.5 patients; 47.8 this after repeated resection. 26.8 patients, at first attempt.Our demonstrates that early neoplasms removed by mostly well differentiated, very rarely show or vessels. Although lesions seem be low risk regard metastatic spread therefore treatable endoscopically, improved methods achieving one-piece (en bloc) should developed.