Clinical and Biochemical Characterization of Women with Polycystic Ovary Syndrome in North Rhine-Westphalia

• DOI: 10.1055/s-2005-870236
• Publication Date: 2005-07-21T15:54:35Z
• Authors: S. Hahn; S. Tan; S. Elsenbruch; B. Quadbeck; B. L. Herrmann; K. Mann; O. E. Janssen
• Keywords: Hyperandrogenism; Hyperinsulinemia; Dyslipidemia

Polycystic ovary syndrome (PCOS), defined as the combination of oligoanovulation and hyperandrogenism, affects more than 5% women reproductive age. Insulin resistance hyperinsulinemia appear to play an important role in its pathogenesis. Here, we will present a characterization PCOS cohort from North Rhine-Westphalia Germany. Clinical features, family history well endocrine metabolic parameters were prospectively recorded 200 successive patients. All patients evaluated for insulin beta-cell-function by oral glucose tolerance test. Patient data compared with those 98 age-matched control women. showed significantly higher BMI, body fat mass androgen levels impaired metabolism. A positive diabetes was frequent (71%) most common abnormality followed obesity (52%) dyslipidemia (46.3%), incidence 31.5% syndrome. C-reactive protein other cardiovascular risk factors frequently elevated even young While clinical characteristics this German heterogeneous, they comparable Caucasian populations.