Comparison of Macropore, Semipermeable, and Nonpermeable Collagen Conduits in Nerve Repair

• DOI: 10.1055/s-2007-1006750
• Publication Date: 2008-11-07T10:33:41Z
• Authors: Daniel Kim; Sean Connolly; Shurun Zhao; Roger Beuerman; Rand Voorhies; David Kline
• Keywords: Semipermeable membrane

Twelve rabbits were used to study functional nerve regeneration through macropore, semipermeable, and nonpermeable collagen conduits. Each animal underwent a 10-mm bilateral resection of posterior tibial nerve. Lesions repaired with macropore tube in one leg, semipermeable or contralaterally. Functional was evaluated at 6 12 weeks post-repair periods. recovery assessed by electrophysiologic analysis conduction velocity, amplitude action potential, area muscle quantitative qualitative histologic myelinated fibers from the distal stumps. The macropore-collagen-tube group showed significantly greater recoveries than collagen-tube groups, based on analyses.