Antiplatelet Activity of Geranylgeraniol Isolated from Pterodon pubescens Fruit Oil is Mediated by Inhibition of Cyclooxygenase-1

• DOI: 10.1055/s-2007-967177
• Publication Date: 2007-05-16T05:13:50Z
• Authors: Nivea Calixto; Maria da Costa e ...; Carlos Gayer; Marsen Coelho; Márcia Paes; Adriane Todeschini
• Keywords: Geranylgeraniol

Geranylgeraniol is a natural isoprenoid with anti-inflammatory properties extracted from the Pterodon pubescens Benth. fruit oil (PpO). In this work, antiplatelet effect of both PpO and geranylgeraniol investigated. ADP-, thrombin- arachidonic acid (AA)-induced aggregation in human rabbit platelets showed prime involvement cascade. The lack any significant inhibition platelet induced by U-46 619 thrombin, associated suppression prostaglandin E2 thromboxane A2 formation demonstrate, for first time, AA metabolisation inhibiting cyclooxygenase enzyme.