Antihepatotoxic Principles of Curcuma longa Rhizomes

• DOI: 10.1055/s-2007-969845
• Publication Date: 2007-04-02T09:29:16Z
• Authors: Yoshinobu Kiso; Yuriko Suzuki; Noriko Watanabe; Yoshiteru Oshima; Hiroshi Hikino
• Keywords: 0301 basic medicine; Mice; 03 medical and health sciences; Carbon Tetrachloride Poisoning; Plant Extracts; Animals; Chemical and Drug Induced Liver Injury; In Vitro Techniques; Rats; 3. Good health

An extract of the crude drug “ukon”, rhizomes CURCUMA LONGA, exhibited intense preventive activity against carbon tetrachloride-induced liver injury IN VIVO and VITRO. The was subjected to fractionation by monitoring VITRO assay methods employing tetrachloride- galactosamine-produced cytotoxicity in primary cultured rat hepatocytes. Curcuminoids were shown possess significant antihepatotoxic action. protective effects some analogues ferulic acid p-coumaric acid, probable metabolites curcuminoids, also evaluated.