Enhanced Acute-Phase Response and Oxidative Stress in Older Adults with Type II Diabetes

• DOI: 10.1055/s-2007-978662
• Publication Date: 2008-11-07T10:01:28Z
• Authors: F. Arnalich; A. Hernanz; D. López-Maderuelo; J. Peña; J. Camacho; R. Madero; J. Vázquez; C. Montiel
• Keywords: TBARS; Thiobarbituric acid

Objective: To test whether oxidative stress could promote a systemic acute-phase response in elderly patients with type II diabetes. Design and Methods: In group of 30 older diabetic poor glycemic control, serum levels lipid peroxides, measured as thiobarbituric acid-reacting substances (TBARS); C-reactive protein (CRP); interleukin (IL)-6 the soluble form its receptor (sIL-6R), were evaluated at baseline after 2 3 months therapeutic intervention. Thirty asymptomatic, untreated individuals abnormal fasting glycemia, but otherwise healthy status, similar age, sex, weight served control group. Results: At baseline, glycemia (8.83 ± 0.67 mmol/l), HbA1C (8.66 0.59%), TBARS (8.68 1.21 µmol/l), CRP (16.05 3.81 mg/l) IL-6 (5.39 1.25 pg/ml) sIL-6R (1425 492 significantly higher than asymptomatic hyperglycemic (p < 0.001). After treatment, decreased respect to values (-9.82% 60 days -13.74% 90 days), did (-14.05% -21.89%, respectively), (-32.71 % -43.86%), (-23.75% -40.63%) (-34.53% -48.49%, respectively). patients, multiple regression showed, each time, that independently correlated CRP, considering dependent variable. Similar correlations found subjects. Conclusion: These results suggest might be implicated promoting state low-grade inflammation