Effects of Calcium Channel Blockers on Steroidogenesis Stimulated by ACTH and cAMP in Isolated Rat Adrenal Cells

• DOI: 10.1055/s-2007-979818
• Publication Date: 2008-11-07T10:04:29Z
• Authors: M. Matsuki; S. Watanabe; M. Ikeda; S. Nishida; T. Saito
• Keywords: Male; Nifedipine; Calcium Channel Blockers; Rats; 3. Good health; Diltiazem; 03 medical and health sciences; 0302 clinical medicine; Adrenocorticotropic Hormone; Verapamil; Adrenal Glands; Cyclic AMP; Animals; Rats, Wistar; Corticosterone; Cells, Cultured

The effects of the calcium channel blockers verapamil, diltiazem, prenylamine and nifedipine on ACTH- cAMP-mediated pathway for steroidogenesis in a suspension solution isolated rat adrenal cells were studied. Steroidogenesis stimulated by ACTH (10(-10) M) or cAMP (10(-3) was not inhibited (10(-4) M), but strongly concentration-dependent manner diltiazem (10(-5) to 10(-4) M).