Red American Ginseng: Ginsenoside Constituents and Antiproliferative Activities of Heat-Processed Panax quinquefolius Roots

• DOI: 10.1055/s-2007-981524
• Publication Date: 2007-07-10T08:02:36Z
• Authors: Chong-Zhi Wang; Han Aung; Ming Ni; Ji-An Wu; Robin Tong; Sheila Wicks; Tong-Chuan He; Chun-Su Yuan
• Keywords: American ginseng; Steaming; Araliaceae

Red Asian ginseng ( Panax C. A. Meyer, Araliaceae) is used in many Oriental countries. In this study, the saponin constituents and anticancer activities of steamed American quinquefolius L.) roots were evaluated. The contents 12 ginsenosides determined using high performance liquid chromatography (HPLC). After steaming treatment (100 - 120 degrees C for 1 h 0.5 4 h), quantity 7 decreased that 5 others increased. content ginsenoside Rg3, a previously recognized compound, increased significantly when root was at 3 h. antiproliferative effects unsteamed (120 2 h) extracts assayed by modified trichrome stain (MTS) method three cancer cell lines (SW-480, HT-29, NSCLC). Heat-processing effect significantly, activity extract from greater than Chemical white red have also been Five representative ginsenosides, Rb1, Rd, Re, Rg2 studied. Ginsenoside Rg3 had most potent effect. are augmented