Sonoran Propolis: Chemical Composition and Antiproliferative Activity on Cancer Cell Lines

• DOI: 10.1055/s-2007-990244
• Publication Date: 2007-11-28T13:06:04Z
• Authors: Javier Hernandez; Francisco Goycoolea; Jael Quintero; Ana Acosta; Marco Castañeda; Zaira Dominguez; Refugio Robles; Luz Vazquez-Moreno; Enrique Velazquez; Humberto Astiazaran; Efraín Lugo; Carlos Velazquez
• Keywords: Propolis; Galangin; Pinocembrin; Chrysin

In this study, we have analyzed the chemical composition and antiproliferative activity of propolis from three different arid semiarid regions Sonora, Mexico. We identified quantitated main constituents by HPLC-MS. The most abundant were pinocembrin, pinobanksin 3-acetate, chrysin. Sonoran had a strong on both murine human cancer cell lines in concentration-dependent manner. CAPE, galangin, xanthomicrol chrysin showed significant cells tested. DNA harvested cultures treated with exhibited ladder internucleosomal cleavage characteristic apoptosis. summary, propolis. These samples possess lines.