An Enantioselective Formal Synthesis of (+)-(R)-α-Lipoic Acid by an l-Proline-Catalyzed Aldol Reaction

• DOI: 10.1055/s-2008-1032022
• Publication Date: 2008-01-25T08:30:14Z
• Authors: Wei Wang; Wenhu Duan; Shilei Zhang; Xiaobei Chen; Jiangang Zhang
• Keywords: 01 natural sciences; 0104 chemical sciences

An efficient, highly stereocontrolled formal synthesis of (+)-( R)-α-lipoic acid was achieved, which utilizes an L-proline-catalyzed highly enantio- and diastereoselective cross-aldol reaction as the key step.