Impact of Prolonged Physical Training on the Pituitary Glucocorticoid Sensitivity Determined by Very Low Dose Intravenous Dexamethasone Suppression Test

• DOI: 10.1055/s-2008-1078727
• Publication Date: 2008-09-23T00:42:16Z
• Authors: T. Silva; C. Longui; C. Faria; M. Rocha; M. Melo; T. Faria; J. Souza e Almeida; L. Hayashi; C. Kater
• Keywords: Basal (medicine); Dexamethasone suppression test; Bioelectrical Impedance Analysis

The activity of the hypothalamic-pituitary-adrenal axis is usually modulated by several stress factors, including exercise. Different responses are induced physical training according to duration and intensity During prolonged training, cortisol remains normal or decreased as a consequence altered secretion, metabolism excretion, possibly changes in glucocorticoid sensitivity. aim this study was evaluate impact on Eighteen cadets Air Force Academy, mean (SD) age: 18.7 (1.0) years, underwent an intensive 6-week preparatory training-period considered adequate inducing significant body composition measured bioelectrical impedance. Measurement individual's pituitary sensitivity done intravenous very low dose dexamethasone suppression test (20 μg/m2) that performed before after period. Cortisol levels were obtained at basal condition 120 minutes infusion. Basal showed decrease training. percent tended be lower Overall, our data suggest able reduce sensitivity, which can have beneficial chronic conditions.