Mammographic Density and the Risk and Detection of Breast Cancer

• DOI: 10.1056/nejmoa062790
• Publication Date: 2007-01-17T17:38:35Z
• Authors: Norman F. Boyd; Helen Guo; Lisa J. Martin; Limei Sun; Jennifer Stone; Eve Fishell; Roberta A. Jong; Greg Hislop; Anna Chiarelli; Salomon Minkin; Martin J. Yaffe
• Keywords: Breast density; Breast Cancer Screening; Cancer screening; Mammographic Density

Extensive mammographic density is associated with an increased risk of breast cancer and makes the detection by mammography difficult, but influence on according to method unknown.We carried out three nested case-control studies in screened populations 1112 matched pairs. We examined association measured percentage baseline mammogram cancer, detection, time since initiation screening, age.As compared women less than 10% mammogram, 75% or more had (odds ratio, 4.7; 95% confidence interval [CI], 3.0 7.4), whether detected screening 3.5; CI, 2.0 6.2) 12 months after a negative examination 17.8; 4.8 65.9). Increased other means, persisted for at least 8 years study entry was greater younger older women. For median age 56 years, 26% all cancers 50% test were attributable mammogram.Extensive strongly between tests. A substantial fraction can be attributed this factor.