Measurement of relative biological effectiveness of protons in human cancer cells using a laser-driven quasimonoenergetic proton beamline

• DOI: 10.1063/1.3551623
• Publication Date: 2011-02-02T23:24:56Z
• Authors: A. Yogo; T. Maeda; T. Hori; H. Sakaki; K. Ogura; M. Nishiuchi; A. Sagisaka; H. Kiriyama; H. Okada; S. Kanazawa; T. Shimomura; Y. Nakai; M. Tanoue; F. Sasao; P. R. Bolton; M. Murakami; T. Nomura; S. Kawanishi; K. Kondo
• Keywords: Relative biological effectiveness

Human cancer cells are irradiated by laser-driven quasimonoenergetic protons. Laser pulse intensities at the 5×1019 W/cm2 level provide source and acceleration field for protons that subsequently transported four energy-selective dipole magnets. The transport line delivers 2.25 MeV with an energy spread of 0.66 a bunch duration 20 ns. survival fraction in vitro from human salivary gland tumor is measured colony formation assay following proton irradiation dose levels up to 8 Gy, which single rate 1×107 Gy/s effective 0.2 1 Hz repetition irradiation. Relative biological effectiveness 10% be 1.20±0.11 using linear transfer 17.1 keV/μm.