Bifurcation analysis and potential landscapes of the p53-Mdm2 module regulated by the co-activator programmed cell death 5

• DOI: 10.1063/1.4934967
• Publication Date: 2015-11-04T18:01:11Z
• Authors: Yuanhong Bi; Zhuoqin Yang; Changjing Zhuge; Jinzhi Lei
• Keywords: Bistability; Limit cycle; Oscillation (cell signaling)

The dynamics of p53 play important roles in the regulation cell fate decisions response to various stresses, and programmed death 5 (PDCD5) functions as a co-activator that modulates dynamics. In present paper, we investigated how are modulated by PDCD5 during deoxyribose nucleic acid damage using methods bifurcation analysis potential landscape. Our results revealed activities display rich under different levels, including monostability, bistability with two stable steady states, oscillations, coexistence state (or states) an oscillatory state. physical properties oscillations were further demonstrated landscape which force attracts system limit cycle attractor, curl flux drives coherent oscillation along cyclic trajectory. We also efficiency induced oscillations. show Hopf can be increasing exhibited clear transition features both barrier height energy dissipation when was close point.