Engineering tools for stimulating wound healing

• DOI: 10.1063/5.0173663
• Publication Date: 2024-04-09T12:37:57Z
• Authors: Emily Lazarus; Lindsay Barnum; Srikanthan Ramesh; Jacob Quint; Mohamadmahdi Sama...; Simon Laflamme; Thomas W. Secord; Tannin Schmidt; Ali Tamayol; Iris V. Rivero
• Keywords: 0301 basic medicine; 0303 health sciences; 610; DegreeDisciplines::Medicine and Health Sciences::Analytical; DegreeDisciplines::Medicine and Health Sciences::Public Health::Environmental Public Health; Diagnostic and Therapeutic Techniques and Equipment::Diagnosis; DegreeDisciplines::Engineering::Computational Engineering

Wound healing is the complex physiological process of restoring skin's integrity, structure, and function after damage caused by external conditions. The wound cascade may be altered due to progression certain diseases, such as diabetes, venous hypertension, or peripheral arterial disease, resulting in non-healing chronic wounds. Chronic wounds can characterized a wide variety pathologies including increased reactive oxygen species, ineffective neutrophil activity, overabundance pro-inflammatory cytokines, hypoxia. Medical intervention crucial heal This review explores current research engineer improved treatment devices, dressings, constructs facilitate tissue regeneration closure. first covers different physical stimulation therapies, then, local therapeutic delivery systems, finally three-dimensional (bio)printing techniques for fabrication skin grafts dressings. Additionally, discusses regulatory bringing cutting-edge technologies market highlights currently approved products treatment. At end, unmet need future directions that field should expand are discussed.