A silica nanobean carrier utilizing lysosomal and mitochondrial autophagy to kill ovarian cancer cell

• DOI: 10.1063/5.0210252
• Publication Date: 2024-05-10T15:48:28Z
• Authors: Shi Tang; Qing Liu; Mingcheng Song; Xiangshuai Li; Degang Ji; Ying-Wei Yang; Huimei Yu
• Keywords: 0301 basic medicine; 03 medical and health sciences; Physics; QC1-999; TP248.13-248.65; Biotechnology

The development of responsive and smart drug nanocarriers that defeat the tumor microenvironment resists cancer therapy has attracted considerable attention in recent decades. Upgrades are sought to effectively increase therapeutic efficacy chemotherapy drugs reduce damage normal tissues. In this study, a new type silica nano-particle carrier, dual-functionalized mesoporous nanobeans (DF-MSNB), is used encapsulate drug, doxorubicin (DOX), form DOX@DF-MSNB complex. complex simultaneously releases tracks uptake by cells after environmentally triggered release encapsulated fluorophore. Upon sensing high GSH level low pH microenvironment, disulfide bond breaks linker between carrier. An attached fluorescent group activated, DOX released from Our results show co-localizes with mitochondria lysosomes A2780 cells, enabling subvert cells’ mitochondrial function activate macrophage autophagy. application autophagy inhibitor confirms inhibits activating