Development of an affine transformation based treatment control system for accelerator based boron neutron capture therapy

• DOI: 10.1063/5.0228761
• Publication Date: 2025-03-03T13:31:16Z
• Authors: Junliang Du; Yongquan Wang; Wenming Zhou; Yang Liu; Jinyang Li; Long Gu
• Keywords: Neutron capture

This study developed and validated an adaptive treatment control system based on affine transformation for accelerator-based boron neutron capture therapy. Accelerator-based therapy is a form of targeted radiotherapy that uses boron-10 to label tumor cells. When these boron-rich cells interact with neutrons, they produce high-linear energy transfer alpha particles lithium-7 particles, effectively destroying the precision. The newly integrates real-time stereoscopic x-ray imaging technology, enabling dynamic adjustments plan by continuously monitoring changes in tumors surrounding tissues. To optimize accuracy, employs algorithm, ensuring precise dose delivery accurate patient positioning. Positioning test results demonstrate excels its core functionality positioning significantly improving adaptability while minimizing damage healthy In addition, introduces device independently designed constructed Lanzhou University. includes detailed description system’s architecture, algorithms, principles behind safety interlock functions. Spatial tests confirmed high overall validating reliability highlighting potential broader applications cancer treatment.