Intralesional corticosteroids as an alternative treatment for central giant cell granuloma

• DOI: 10.1067/moe.2002.119971
• Publication Date: 2002-08-24T22:14:26Z
• Authors: Roman Carlos; Heddie O. Sedano
• Keywords: Adult; Male; Epinephrine; Anti-Inflammatory Agents; Injections, Intralesional; Triamcinolone; 3. Good health; Drug Combinations; 03 medical and health sciences; 0302 clinical medicine; Clinical Protocols; Granuloma, Giant Cell; Child, Preschool; Humans; Female; Anesthetics, Local; Child; Jaw Diseases

Four cases of central giant cell granuloma were treated with intralesional infiltration of a solution of Kenacort-A (10 mg/mL, triamcinolone aqueous suspension SQUIBB) and either (1) Lidocaine 2% with epinephrine 1:200,000 Marcaine or (2) Bupivacaine, 50% mixture by volume. These cases were originally diagnosed by radiographic and histologic studies in 3 Guatemalan males--ages 31, 34, and 6 years old--and a 21/2-year-old Guatemalan girl. The average dosage of the aforementioned solution was 6 mL (equivalent to 30 mg of triamcinolone) for the adults and 5 mL (equivalent to 25 mg of triamcinolone) for the pediatric patients. Before treatment, an endocrinologist evaluated all of the patients to rule out hyperparathyroidism. Also before treatment, an incisional biopsy of the lesion was obtained from each patient for microscopic examination. Follow-up radiographs for all the cases showed progressive improvement and eventual resolution of the lesions.