Carbocyclic nucleoside analogues: classification, target enzymes, mechanisms of action and synthesis

• DOI: 10.1070/rc2012v081n08abeh004314
• Publication Date: 2012-10-01T10:41:29Z
• Authors: E S Matyugina; A P Khandazhinskaya; Sergei N Kochetkov
• Keywords: Nucleoside analogue

Key biological targets (S-adenosyl-L-homocysteine hydrolase, telomerase, human immunodeficiency virus reverse transcriptase, herpes DNA polymerase and hepatitis B polymerase) the mechanisms of action carbocyclic nucleoside analogues are considered. Structural types discussed. Methods synthesis for most promising compounds spectrum their activities described. The bibliography includes 126 references.