Cyanosilylation of Aldehydes Catalyzed by Iron(III) Arylhydrazone-β-Diketone Complexes

• DOI: 10.1071/ch17595
• Publication Date: 2018-02-20T05:07:19Z
• Authors: Atash V. Gurbanov; Abel M. Maharramov; Fedor I. Zubkov; Alexander M. Saif...; Firudin I. Guseinov
• Keywords: Trimethylsilyl cyanide; Cyanohydrin; Trimethylsilyl; Biocatalysis

Two known iron(iii) complexes, [Fe(H2O)3(L1)]·xH2O (x = 4 (1), 5 (2)) and [Fe(H2O)3(L2)]·3H2O (3), bearing the basic forms of 5-chloro-3-(2-(4,4-dimethyl-2,6-dioxocyclohexylidene)hydrazinyl)-2-hydroxybenzenesulfonic acid (H3L1) 3-(2-(2,4-dioxopentan-3-ylidene)hydrazinyl)-2-hydroxy-5-nitrobenzenesulfonic (H3L2), were prepared used as homogeneous catalysts for cyanosilylation a variety aldehydes with trimethylsilyl cyanide leading to corresponding cyanohydrin ethers. High yield (up 98 %) was observed in reaction catalyzed by 3 at room temperature methanol.