The role of insulin-like growth factor II and its receptor in mouse preimplantation development

• DOI: 10.1071/rd02031
• Publication Date: 2003-08-20T07:03:48Z
• Authors: M. Pantaleon; H. Jericho; G. Rabnott; P. L. Kaye
• Keywords: 0301 basic medicine; Zygotic Genome; Mitosis; Embryonic Development; Fluorescent Antibody Technique; Antisense Inhibition; Receptor, IGF Type 2; In-vitro Fertilization; Oligodeoxyribonucleotides, Antisense; Tissue Culture Techniques; Mice; 03 medical and health sciences; Glucose Transport; Embryos Invitro; C1; Mannose 6-phosphate; Insulin-Like Growth Factor II; Pregnancy; Inner Cell Mass; 616; 730215 Nutrition; Animals; 270602 Animal Physiology - Cell; Mice, Knockout; Reproductive Biology; Microscopy, Confocal; Glucose-transport; 270000 Biological Sciences; Biological Transport; Embryo Culture; 730116 Reproductive system and disorders; Blastocyst; Glucose; Igf-i; Blastocysts; Female; Morphological Development; 300406 Animal Growth and Development; Zoology; Stimulates Growth; Developmental Biology

Insulin-like growth factor II (IGF-II) and its receptor, the IGF-II/mannose-6-phosphate (IGF-II/M6P) are first expressed from zygotic genome at two-cell stage of mouse development. However, their role is not clearly defined. believed to mediate through heterologous type 1 IGF insulin receptors, whereas IGF-II/M6P receptor act as a negative regulator somatic by limiting availability excess levels IGF-II. These studies demonstrate that IGF-II does have in regulation early embryo receptor. stimulated cleavage rate embryos vitro. Moreover, this required for glycaemic response normal progression blastocyst stage. Improved development crowded culture supports concept an endogenous embryonic paracrine activity enhances cell proliferation. responses indicate functional likely participate such regulatory circuit. The discussed with reference