Prepubertal male rats with high rates of germ-cell apoptosis present exacerbated rates of germ-cell apoptosis after serotonin depletion

• DOI: 10.1071/rd13382
• Publication Date: 2014-11-20T00:52:24Z
• Authors: Néstor Méndez Pal...; María Elena Ayala...; Maximino Méndez M...; Rubén Huerta Crispín; Octavio Guerrero ...; Javier Hernández ...; Andrés Aragón Mar...
• Keywords: Male; 0301 basic medicine; Serotonin; Progesterone Reductase; Gene Expression Regulation, Developmental; Apoptosis; Receptors, Cell Surface; Hydroxyindoleacetic Acid; Spermatogonia; Rats; Kinetics; Random Allocation; 03 medical and health sciences; Serotonin Agents; Proto-Oncogene Proteins c-bcl-2; Receptors, Androgen; Animals; RNA, Messenger; Sexual Maturation; Spermatogenesis; p-Chloroamphetamine; bcl-2-Associated X Protein

Male germ-cell apoptosis occurs naturally and can be increased by exposure to drugs toxic chemicals. Individuals may have different rates of are likely also exhibit differential sensitivity outside influences. Previously, we reported that p-chloroamphetamine (pCA), a substance inhibits serotonin synthesis, induced in prepubertal male rats. Here, identified rats with high or low evaluated gene expression both groups. Bax Shbg mRNA levels were higher apoptosis. Rats then treated pCA the neuro-hormonal response evaluated. Treatment reduction concentrations but sex hormones gonadotrophins not changed. initially had even after treatment pCA. In remained On basis category, an inverse relationship between Bcl2, AR Hsd3b2 was found. Here provide evidence innate could explained level genes involved spermatogenesis.