Toll-like receptor expression patterns in the rat uterus during post partum involution

• DOI: 10.1071/rd16431
• Publication Date: 2017-07-13T02:36:02Z
• Authors: Emel Alan; Narin Liman
• Keywords: Involution (esoterism); Myometrium

Toll-like receptors (TLRs) belong to a family of pathogen recognition and play critical roles in detecting responding invading pathogens. TLR expression could be significant because, the uterus, reproductive tract is an important site exposure infection by pathogens during post partum involution period. To clarify localisation patterns TLRs rat uterus on Days 1, 3, 5 10 (PP1, PP3, PP5 PP10 respectively), immunohistochemistry western blotting were used analyse TLR1–7, TLR9 TLR10. The results indicated that TLR10 localised both cytoplasm nuclei luminal glandular epithelium, stromal fibroblasts myometrial cells uterus. In TLR4–7 also found lateral membranes, whereas was present apical membranes. Western blot analysis revealed proteins increased with number days partum, reaching maximum PP10, although levels did not differ significantly from those PP1 (P > 0.05). These findings confirm are constitutively expressed uterine pattern endometrium varies structural changes different involution. suggest may role repair remodelling physiological