Caveolin-1 promotes trophoblast cell invasion through the focal adhesion kinase (FAK) signalling pathway during early human placental development

• DOI: 10.1071/rd18296
• Publication Date: 2019-04-04T00:21:17Z
• Authors: Zhihui Dai; Fei Sheng; Ningxia Sun; Yixuan Ji; Qiuying Liao; Shuhan Sun; Fu Yang; Wen Li
• Keywords: Trophoblast; KEGG

Normal implantation and placental development depend on the appropriate differentiation invasion of trophoblast cells. Inadequate cell results in pregnancy-related disorders, which endanger both mother fetus; however, mechanism early has not been fully explained. In this study we conducted gene expression profile analysis using mouse tissues at different developmental stages (embryonic day (E)7.5, E14.5 E19.5) series tests cluster (STC) Kyoto Encyclopaedia Genes Genomes (KEGG) pathway analyses. Focal adhesion kinase (FAK) signalling pathway-related levels were verified quantitative reverse transcription polymerase chain reaction western blot. The showed that caveolin-1 (Cav1) was downregulated placenta unexplained spontaneous abortion subjects compared with induced abortion. Furthermore, by modulating CAV1 levels, shown to promote human proliferation, migration activating FAK pathway. These indicate are crucial for development, sheds new light our understanding mechanisms placenta.