High levels of Y-chromosome nucleotide diversity in the genusPan

• DOI: 10.1073/pnas.012364999
• Publication Date: 2002-07-26T14:36:44Z
• Authors: Anne C. Stone; Robert C. Griffiths; Stephen L. Zegura; Michael F. Hammer
• Keywords: Pan paniscus; Subspecies; Bonobo; Troglodytes; Nucleotide diversity

Although some mitochondrial, X chromosome, and autosomal sequence diversity data are available for our closest relatives, Pan troglodytes paniscus , from the nonrecombining portion of Y chromosome (NRY) more limited. We examined ≈3 kb NRY DNA 101 chimpanzees, seven bonobos, 42 humans to investigate: ( i ) relative levels intraspecific diversity; ii degree paternal lineage sorting among species subspecies genus ; iii date chimpanzee/bonobo divergence. identified 10 informative sequence-tagged sites associated with 23 polymorphisms on . Nucleotide was significantly higher chimpanzees bonobos than human NRY. Similar mtDNA, but unlike X-linked loci, lineages defined by mutations were not shared P. Comparisons mtDNA ND2 sequences same individuals revealed a larger female versus male effective population size chimpanzees. The NRY-based divergence time between estimated at ≈1.8 million years ago. In contrast populations who appear have had low recent origin subsequent growth, taxa within may be characterized large relatively constant size, ancient origins, high subdivision.