Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis

• DOI: 10.1073/pnas.0308671100
• Publication Date: 2004-02-25T04:03:03Z
• Authors: Ebba Bråkenhielm; Niina Veitonmäki; Renhai Cao; Shinji Kihara; Yuji Matsuzawa; Boris Zhivotovsky; Tohru Funahashi; Yihai Cao
• Keywords: Male; Fibrosarcoma; Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Chick Embryo; Chorion; Capillaries; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Allantois; Cell Movement; Caspases; Cell Line, Tumor; Animals; Humans; Intercellular Signaling Peptides and Proteins; Cattle; Female; Adiponectin; Collagen; Endothelium, Vascular

Obesity is a risk factor for the development of many severe human diseases such as cardiovascular disorders, diabetes, and cancer, which are tightly linked to angiogenesis. The adipose tissue produces several growth factors/hormones including leptin, tumor necrosis α, adiponectin. It has been found that adiponectin levels reduced in obesity. Here, we report unique function negative regulator In vitro , potently inhibits endothelial cell proliferation migration. chick chorioallantoic membrane mouse corneal angiogenesis assays, remarkably prevents new blood vessel growth. Further, demonstrate antiendothelial mechanisms involve activation caspase-mediated apoptosis. Adiponectin induces cascade caspases-8, -9, -3, leads death. model, significantly primary Impaired associated with decreased neovascularization, leading increased These data induction apoptosis an mechanism adiponectin-induced antiangiogenesis. Adiponectin, direct endogenous inhibitor, may have therapeutic implications treatment angiogenesis-dependent diseases.