Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging

• DOI: 10.1073/pnas.0400285101
• Publication Date: 2004-04-27T00:54:03Z
• Authors: Scott A. Small; Monica K. Chawla; Michael Buonocore; Peter R. Rapp; Carol A. Barnes
• Keywords: Parahippocampal gyrus; Subiculum

The hippocampal formation contains a distinct population of neurons organized into separate anatomical subregions. Each subregion expresses unique molecular profile accounting for their differential vulnerability to mechanisms memory dysfunction. Nevertheless, it remains unclear which is most sensitive the effects advancing age. Here we investigate this question by using imaging techniques, each assessing different correlates neuronal function. First, used MRI map cerebral blood volume, an established correlate basal metabolism, in subregions young and old rhesus monkeys. Second, situ hybridization Arc expression rats. immediate early gene that activated behavior-dependent manner correlated with spike activity. Results show dentate gyrus age, together prior studies establishes cross-species consensus. This pattern isolates locus age-related dysfunction differentiates normal aging from Alzheimer's disease.